Levosimendan restores the positive force-frequency relation in heart failure
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چکیده
منابع مشابه
Levosimendan restores the positive force-frequency relation in heart failure.
Frequency potentiation of contractile function is a major mechanism of the increase in myocardial performance during exercise. In heart failure (HF), this positive force-frequency relation is impaired, and the abnormal left ventricular (LV)-arterial coupling is exacerbated by tachycardia. A myofilament Ca(2+) sensitizer, levosimendan, has been shown to improve exercise tolerance in HF. This may...
متن کاملAltered myocardial force-frequency relation in human heart failure.
BACKGROUND In congestive heart failure (idiopathic dilated cardiomyopathy), exercise is accompanied by a smaller-than-normal decrease in end-diastolic left ventricular volume, depressed peak rates of left ventricular pressure rise and fall, and depressed heart-rate-dependent potentiation of contractility (bowditch treppe). We studied contractile function of isolated left ventricular myocardium ...
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Heart failure is a relatively important public health problem due to its increasing incidence, poor prognosis, and frequent need of re-hospitalization. Intravenous positive inotropic agents play an important role in treating acute decompensation of patients with heart failure due to left ventricular systolic dysfunction. Although frequently used, the inotropic agents beta-adrenergic agonists an...
متن کاملBiventricular pacing improves the blunted force-frequency relation present during univentricular pacing in patients with heart failure and conduction delay.
BACKGROUND In patients with chronic heart failure (CHF) and conduction delay, biventricular (BiV) and left ventricular (LV) pacing similarly improve systolic function at resting heart rates. We hypothesized that BiV and univentricular pacing differentially affect contractile function at increasing heart rates. METHODS AND RESULTS Twenty-two patients (aged 66+/-2 years, QRS 179+/-8 ms, LV ejec...
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Acute heart failure (AHF) is one of the main causes of cardiovascular morbidity and mortality. After diagnosis of AHF and during the first year of followup, 45% of the patients will be admitted to hospital at least once and mortality can be as high as 40%.1 Therapeutic approaches are therefore needed to alleviate symptoms, stabilize the hemodynamics of the patients, and improve their quality of...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2011
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.01116.2010